Allopurinol and heart failure

Allopurinol and heart failure

Study Design Randomization Parallel Open-label. Background: Hyperuricemia is associated with reduced survival among patients with heart failure (HF), but the effect of gout on HF outcomes is unknown. The effect of urate lowering drugs (ULT) and, in particular, the xanthine oxidase inhibitor in patients with HF is controversial. Further work allopurinol and heart failure is required to substantiate or refute this fi …. The aim of the study is to co …. Hyperuricaemia predicts poor outcome in patients with mild to moderate chronic heart failure. A recent randomized trial suggested that allopurinol may reduce adverse outcomes among patients with hyperuricemia and HF The ALL-HEART trial failed to show that allopurinol improves cardiovascular outcomes among patients with ischemic heart disease. Jankowska EAPonikowska BMajda J et al. Description: The goal of the trial was to evaluate allopurinol compared with usual care among patients with ischemic heart disease. Methods: The Prospective Randomized Amlodipine Survival Evaluation study included New York Heart Association class IIIB or IV patients with left ventricular ejection fraction. Effect of Allopurinol in Patients With HF and a Remote History of Gout 1. Int J Cardiol2007;115 (2) 151- 155PubMedGoogle Scholar 2. Background: Previous studies have not extensively examined the association of hyperuricemia and adverse outcomes in systolic heart failure (HF) in relation to xanthine oxidase inhibitor therapy. Long term high dose allopurinol may be associated with a better mortality than long term low dose allopurinol in patients with CHF because of a dose related beneficial effect of allopurinol against the well described allopurinol and heart failure adverse effect of urate.

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